Hailing from Boston, Misha Collins garnered his first acting work primarily with small roles in various theatrical films and television programs, including the short-lived Western series "Legacy," an uncredited bit in Barry Levinson's music-infused coming-of-age drama "Liberty Heights," and the supernatural fantasy show "Charmed." A turn in the widely talked-about institution drama "Girl, Interrupted" primed Collins for his big break on the hit FOX suspense show "24," playing a deadly assassin for a number of episodes during the show's first season. In 2006, he stuck with the successful killer motif to star as murderer Paul Bernardo in the controversial docudrama "Karla," based on the true case of Bernardo and his girlfriend Karla Homolka, who raped and murdered three teenage girls (including Homolka's sister). The film generated plenty of criticism in Canada where the murders took place. Despite the controversy, Collins is arguably best known for his role as the deadly serious, deadpan angel Castiel on the hit dark fantasy show "Supernatural."